2,321 research outputs found

    Alien Registration- Messer, Myrtle B. (Moscow, Somerset County)

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    https://digitalmaine.com/alien_docs/9285/thumbnail.jp

    Time-dependent Schr\"odinger equations having isomorphic symmetry algebras. I. Classes of interrelated equations

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    In this paper, we focus on a general class of Schr\"odinger equations that are time-dependent and quadratic in X and P. We transform Schr\"odinger equations in this class, via a class of time-dependent mass equations, to a class of solvable time-dependent oscillator equations. This transformation consists of a unitary transformation and a change in the ``time'' variable. We derive mathematical constraints forthe transformation and introduce two examples.Comment: LaTeX, 18 pages, new format, edite

    Investigations into the Sarcomeric Protein and Ca2+-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats (Felix catus).

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    Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere. We therefore investigated contractile and regulatory proteins in left ventricular tissue from 25 cats, 18 diagnosed with HCM, including a Ragdoll cat with a homozygous MYBPC3 R820W, and 7 non-HCM cats in comparison with human HCM (from septal myectomy) and donor heart tissue. Myofibrillar protein expression was normal except that we observed 20–44% MyBP-C haploinsufficiency in 5 of the HCM cats. Troponin extracted from 8 HCM and 5 non-HCM cat hearts was incorporated into thin filaments and studied by in vitro motility assay. All HCM cat hearts had a higher (2.06 ± 0.13 fold) Ca2+-sensitivity than non-HCM cats and, in all the HCM cats, Ca2+-sensitivity was not modulated by troponin I phosphorylation. We were able to restore modulation of Ca2+-sensitivity by replacing troponin T with wild-type protein or by adding 100 μM Epigallocatechin 3-gallate (EGCG). These fundamental regulatory characteristics closely mimic those seen in human HCM indicating a common molecular mechanism that is independent of the causative mutation. Thus, the HCM cat is a potentially useful large animal model

    Ascertaining the Core Collapse Supernova Mechanism: An Emerging Picture?

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    Here we present the results from two sets of simulations, in two and three spatial dimensions. In two dimensions, the simulations include multifrequency flux-limited diffusion neutrino transport in the "ray-by-ray-plus" approximation, two-dimensional self gravity in the Newtonian limit, and nuclear burning through a 14-isotope alpha network. The three-dimensional simulations are model simulations constructed to reflect the post stellar core bounce conditions during neutrino shock reheating at the onset of explosion. They are hydrodynamics-only models that focus on critical aspects of the shock stability and dynamics and their impact on the supernova mechanism and explosion. In two dimensions, we obtain explosions (although in one case weak) for two progenitors (11 and 15 Solar mass models). Moreover, in both cases the explosion is initiated when the inner edge of the oxygen layer accretes through the shock. Thus, the shock is not revived while in the iron core, as previously discussed in the literature. The three-dimensional studies of the development of the stationary accretion shock instability (SASI) demonstrate the fundamentally new dynamics allowed when simulations are performed in three spatial dimensions. The predominant l=1 SASI mode gives way to a stable m=1 mode, which in turn has significant ramifications for the distribution of angular momentum in the region between the shock and proto-neutron star and, ultimately, for the spin of the remnant neutron star. Moreover, the three-dimensional simulations make clear, given the increased number of degrees of freedom, that two-dimensional models are severely limited by artificially imposed symmetries.Comment: 9 pages, 3 figure

    HLA-G: expression in human keratinocytes in vitro and in human skin in vivo

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    Classical, polymorphic major histocompatibility complex class I molecules are expressed on most nucleated cells.They present peptides at the cell surface and, thus, enable the immune system to scan peptides for their antigenicity. The function of the other, nonclassical class I molecules in man is controversial. HLA-G which has been shown by transfection experiments to be expressed at the cell surface, is only transcribed in placental tissue and in the fetal eye.Therefore, a role of HLA-G in the control of rejection of the allogeneic fetus has been discussed. We found that HLA-G expression is induced in keratinocytes by culture in vitro. Three different alternative splicing products of HLA-G can be detected: a full length transcript, an mRNA lacking exon 3 and a transcript devoid of exon 3 and 4. Reverse transcription followed by polymerase chain reaction also revealed the presence of HLA-G mRNA in vivo in biopsies of either diseased or healthy skin

    An adjudicated hermeneutic single-case efficacy design study of experiential therapy for panic/phobia

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    This paper illustrates the application of an adjudicated form of Hermeneutic Single Case Efficacy Design (HSCED), a critical-reflective method for inferring change and therapeutic influence in single therapy cases. The client was a 61 year-old European-American male diagnosed with panic and bridge phobia. He was seen for 23 sessions of individual Process-Experiential/Emotion-Focused Therapy. In this study, affirmative and skeptic teams of researchers developed opposing arguments regarding whether the client changed over therapy and whether therapy was responsible for these changes. Three judges representing different theoretical orientations then assessed data and arguments, rendering judgments in favor of the affirmative side. We discuss clinical implications and recommendations for the future interpretive case study research

    Sediment-Phosphorus Relationships in Deer Creek Reservoir

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    Summary and Conclusions: Laboratory analyses of sediment samples recovered from Deer Creek Reservoir showed the sediments to have amoderate potential for serving as a source of phosphorus (P) for the overlying water solumn under anaerobic conditions. This source could account for the occurrence or exacerbation of blue-green algal blooms in the upper end of the reservoir when the sediment surface becomes anaerobic late in the summer. It could also delay the response of the reservoir to programs that decrease external P loading, if the upper end of the reservoir still has large enough algal blooms to render the sediment-water interface anaerobic. The redox cycle of Fe is closely associated with P release in the reservoir sediments, and aerobic P release rates are probably insignificant in the phosphorus budget of the reservoir. Sediment profiles indicate that the tropich state of the lake has probably not changed significantly since the reservoir was first filled. The profiles do indicate, however, that much of the P input to the lake may be in the relatively unreactive apatite-P traction, and attempts at reducing P loading from external sources should take into account the degree of availability of the P thus removed

    Neutrino-driven supernovae: Boltzmann neutrino transport and the explosion mechanism

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    Core-collapse supernovae are, despite their spectacular visual display, neutrino events. Virtually all of the 10^53 ergs of gravitational binding energy released in the formation of the nascent neutron star is carried away in the form of neutrinos and antineutrinos of all three flavors, and these neutrinos are primarily responsible for powering the explosion. This mechanism depends sensitively on the neutrino transport between the neutrinospheres and the shock. In light of this, we have performed a comparison of multigroup Boltzmann neutrino transport (MGBT) and multigroup flux-limited diffusion (MGFLD) in post-core bounce environments. Differences in the mean inverse flux factors, luminosities, and RMS energies translate to heating rates that are up to 2 times larger for Boltzmann transport, with net cooling rates below the gain radius that are typically 0.8 times the MGFLD rates. These differences are greatest at earlier postbounce times for a given progenitor mass, and for a given postbounce time, greater for greater progenitor mass. The increased differences with increased progenitor mass suggest that the net heating enhancement from MGBT is potentially robust and self-regulated.Comment: 7 pages, 2 figures, 1 table; LaTex using iopconf.sty; To appear in: Proceedings of The Second Oak Ridge Symposium on Atomic & Nuclear Astrophysic
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